Article
Minimum infectious dose of hepatitis B virus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C.
Transfusion - 1 Feb 2008
Komiya Yutaka, Katayama Keiko, Yugi Hisao, Mizui Masaaki, Matsukura Harumichi, Tomoguri Tetsushi, Miyakawa Yuzo, Tabuchi Ayako, Tanaka Junko, Yoshizawa Hiroshi
Abstract excerpt
BACKGROUND: In planning optimal hepatitis B virus (HBV) blood screening strategies, the minimum infectious dose and early dynamics of HBV need to be determined for defining the window period for HBV DNA as well as for hepatitis B surface antigen (HBsAg). STUDY DESIGN AND METHODS: Pairs of chimpanzees were inoculated with preacute-phase inocula containing HBV of genotype A or genotype C to determine the minimum...
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