Article
L-arginine exacerbates experimental cerebral malaria by enhancing pro-inflammatory responses.
The Tohoku journal of experimental medicine - 1 May 2015
Xu Hongbin, Feng Yonghui, Chen Guang, Zhu Xiaotong, Pang Wei, Du Yunting, Wang Qinghui, Qi Zanmei, Cao Yaming
Abstract excerpt
L-Arginine (L-Arg), the substrate for nitric oxide (NO) synthase, has been used to treat malaria to reverse endothelial dysfunction in adults. However, the safety and efficacy of L-Arg remains unknown in malaria patients under the age of five, who are at the greatest risk of developing cerebral malaria (CM), a severe malaria complication. Here, we tested effects of L-Arg treatment on the outcomes of CM using a...
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