Structural epitope matching for HLA‐alloimmunized thrombocytopenic patients: a new strategy to provide more effective platelet transfusion support?

Abstract excerpt

BACKGROUND: During the past three decades, HLA matching for platelet (PLT) transfusion of refractory thrombocytopenic patients has been based on serologic cross-reactivity between HLA-A and HLA-B antigens. Although many blood banks are using this matching strategy, the general experience is that such matched PLT transfusions are often ineffective. STUDY DESIGN AND METHODS: This report describes a new HLA matching...

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