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Article

CpG Island hypermethylation in cell‐free serum DNA identifies patients with localized prostate cancer

14 Nov 2007

Abstract excerpt

BACKGROUND: One of the earliest and most common epigenetic events in prostate carcinogenesis is DNA CpG island (CGI) hypermethylation. Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients. METHODS: We analyzed serum samples from 226 consecutive patients (168 PCA; 42 benign prostatic hyperplasia (BPH); 5...

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PMID: 18004747
DOI: 10.1002/pros.20651

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