Article
Glutathione S-transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis.
British journal of clinical pharmacology - 1 Apr 1995
Green V J, Pirmohamed M, Kitteringham N R, Knapp M J, Park B K
Abstract excerpt
1. Tacrine (1,2,3,4-tetrahydro-9-aminoacridine) which is used in Alzheimer's disease, causes elevation of liver transaminases ('tacrine transaminitis') in 40-50% of patients. This may be related to the formation of a chemically reactive metabolite from tacrine, which can be detoxified in vitro by...
Topics
- Adolescent
- Adult
- Aged
- Alzheimer Disease
- Base Sequence
- Confidence Intervals
- DNA Primers
- Electrophoresis, Agar Gel
- Female
- Gene Deletion
- Gene Frequency
- Genotype
- Glutathione Transferase
- Humans
- Liver
- Male
- Middle Aged
- Molecular Sequence Data