Article
X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate.
American journal of medical genetics. Part A - 15 Dec 2007
Kimani Jane W, Shi Min, Daack-Hirsch Sandra, Christensen Kaare, Moretti-Ferreira Danilo, Marazita Mary L, Field L Leigh, Canady John W, Murray Jeffrey C
Abstract excerpt
Nonsyndromic clefts of the lip and/or palate are common birth defects with a strong genetic component. Based on unequal gender ratios for clefting phenotypes, evidence for linkage to the X chromosome and the occurrence of several X-linked clefting syndromes, we investigated the role of skewed X chromosome inactivation (XCI) in orofacial clefts. Our samples consisted of female monozygotic (MZ) twins (n = 8) and...
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