Article
A comparison of the lengths of androgen receptor triplet repeats in brain and blood in motor neuron diseases.
Journal of the neurological sciences - 15 Apr 2008
Saunderson Rebecca B, Yu Bing, Trent Ronald J A, Pamphlett Roger
Abstract excerpt
BACKGROUND: Expansions of triplet repeats are found in a number of neurodegenerative conditions, and different tissues in the same person can have varying repeat lengths. In Kennedy disease, motor neuron loss is due to expansion of the CAG repeat length in the androgen receptor gene (AR). We hypothesised that patients with other sporadic motor neuron diseases could have AR expansions that were restricted to CNS...
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