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Article

Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification.

The Journal of pathology - 1 Feb 2008

Angulo B, Suarez-Gauthier A, Lopez-Rios F, Medina P P, Conde E, Tang M, Soler G, Lopez-Encuentra A, Cigudosa J C, Sanchez-Cespedes M

Abstract excerpt

The development of targeted therapies creates a need to discriminate tumours accurately by their histological and genetic characteristics. Here, we aim to identify gene expression profiles and single markers that recapitulate the pathological and genetic background of non-small cell lung cancer (NSCLC). We performed cDNA microarray analysis on a series of 69 NSCLCs, with known mutation status for important genes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17992665
DOI: 10.1002/path.2267

Genes

EGFR
KRAS
PRODH
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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