Article
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic.
Traffic (Copenhagen, Denmark) - 1 Oct 2006
Pryor Paul R, Reimann Frank, Gribble Fiona M, Luzio J Paul
Abstract excerpt
Mucolipin-1 is a membrane protein encoded by the gene MCOLN1, mutations in which result in the lysosomal storage disorder mucolipidosis type IV (MLIV). Efficient lysosomal targeting of mucolipin-1 requires di-leucine motifs in both the N-terminal and the C-terminal cytosolic tails. We have shown that aberrant lactosylceramide trafficking in MLIV cells may be rescued by wild-type mucolipin-1 expression but not by...
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