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Article

Beta-strand flipping and slipping triggered by turn replacement reveal the opportunistic nature of beta-strand pairing.

Journal of the American Chemical Society - 28 Nov 2007

Makabe Koki, Yan Shude, Tereshko Valentina, Gawlak Grzegorz, Koide Shohei

Abstract excerpt

We investigated how the register between adjacent beta-strands is specified using a series of mutants of the single-layer beta-sheet (SLB) in Borrelia OspA. The single-layer architecture of this system eliminates structural restraints imposed by a hydrophobic core, enabling us to address this question. A critical turn (turn 9/10) in the SLB was replaced with a segment with an intentional structural mismatch. Its...

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Identifiers

PMID: 17985889
DOI: 10.1021/ja074252c
PMCID: PMC2596595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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