Article
Detection of six single-nucleotide polymorphisms associated with rheumatoid arthritis by a loop-mediated isothermal amplification method and an electrochemical DNA chip.
Analytical chemistry - 15 Dec 2007
Nakamura Naoko, Ito Keiko, Takahashi Masayoshi, Hashimoto Koji, Kawamoto Manabu, Yamanaka Mariko, Taniguchi Atsuo, Kamatani Naoyuki, Gemma Nobuhiro
Abstract excerpt
An electrochemical DNA chip using an electrochemically active intercalator and DNA probe immobilized on a gold electrode has been developed for genetic analysis. In this study, the six polymorphisms associated with rheumatoid arthritis (RA), N-acetyltransferase2 (NAT2) gene polymorphisms T341C, G590A, and G857A, methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms C677T and A1298C, and serum amyloid A1...
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