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Article

Characterization of DNA-binding activity of Z alpha domains from poxviruses and the importance of the beta-wing regions in converting B-DNA to Z-DNA.

Nucleic acids research - 1 Jan 2007

Quyen Dong Van, Ha Sung Chul, Lowenhaupt Ky, Rich Alexander, Kim Kyeong Kyu, Kim Yang-Gyun

Abstract excerpt

The E3L gene is essential for pathogenesis in vaccinia virus. The E3L gene product consists of an N-terminal Z alpha domain and a C-terminal double-stranded RNA (dsRNA) binding domain; the left-handed Z-DNA-binding activity of the Z alpha domain of E3L is required for viral pathogenicity in mice....

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PMID: 17984076
DOI: 10.1093/nar/gkm748
PMCID: PMC2190711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17984076-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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