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Article

A role for Z-DNA binding in vaccinia virus pathogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003

Kim Yang-Gyun, Muralinath Maneesha, Brandt Teresa, Pearcy Matthew, Hauns Kevin, Lowenhaupt Ky, Jacobs Bertram L, Rich Alexander

Abstract excerpt

The N-terminal domain of the E3L protein of vaccinia virus has sequence similarity to a family of Z-DNA binding proteins of defined three-dimensional structure and it is necessary for pathogenicity in mice. When other Z-DNA-binding domains are substituted for the similar E3L domain, the virus retains its lethality after intracranial inoculation. Mutations decreasing Z-DNA binding in the chimera correlate with...

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Identifiers

PMID: 12777633
DOI: 10.1073/pnas.0431131100
PMCID: PMC165815

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