Article
A role for Z-DNA binding in vaccinia virus pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003
Kim Yang-Gyun, Muralinath Maneesha, Brandt Teresa, Pearcy Matthew, Hauns Kevin, Lowenhaupt Ky, Jacobs Bertram L, Rich Alexander
Abstract excerpt
The N-terminal domain of the E3L protein of vaccinia virus has sequence similarity to a family of Z-DNA binding proteins of defined three-dimensional structure and it is necessary for pathogenicity in mice. When other Z-DNA-binding domains are substituted for the similar E3L domain, the virus retains its lethality after intracranial inoculation. Mutations decreasing Z-DNA binding in the chimera correlate with...
Topics
- Adenosine Deaminase
- Amino Acid Sequence
- Animals
- Chimera
- DNA, Viral
- DNA-Binding Proteins
- Glycoproteins
- Mice
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- RNA-Binding Proteins