Article
Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: results from The Netherlands Cohort Study on diet and cancer.
World journal of urology - 1 Feb 2008
Smits Kim M, Schouten Leo J, van Dijk Boukje A C, van Houwelingen Kjeld, Hulsbergen-van de Kaa Christina A, Kiemeney Lambertus A L M, Goldbohm R Alexandra, Oosterwijk Egbert, van den Brandt Piet A
Abstract excerpt
Metabolic gene polymorphisms have previously been suggested as risk factors for renal cell carcinoma (RCC). These polymorphisms are involved in activation or detoxification of carcinogens in cigarette smoke which is another RCC risk factor. We evaluated gene-environment interactions between CYP1A1, GSTmicro1 and smoking in a large population-based RCC case group. The Netherlands Cohort Study on diet and cancer...
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