Article
Anterior segment dysgenesis after overexpression of transforming growth factor-beta-induced gene, beta igh3, in the mouse eye.
Molecular vision - 16 Oct 2007
Kim Jung-Eun, Han Min-Su, Bae Yong-Chul, Kim Hong-Kyun, Kim Tae-Im, Kim Eung Kweon, Kim In-San
Abstract excerpt
PURPOSE: Beta igh3 is a transforming growth factor-beta-inducible cell adhesion molecule and its mutations are responsible for human autosomal dominant corneal dystrophies. Previously, we have studied the molecular properties of beta igh3 in vitro and reported that beta igh3 polymerizes to form a fibrillar structure and interacts with several extracellular matrix proteins including type I collagen. This study...
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