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Article

Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.

Nucleic acids research - 1 Jan 2007

Mourgues Sophie, Lomax Martine E, O'Neill Peter

Abstract excerpt

Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is approximately 4x less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whethe...

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Source

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Identifiers

PMID: 17982170
DOI: 10.1093/nar/gkm947
PMCID: PMC2190709

Genes

SSB
HAP1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17982170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency.PMID 17982170Read ↗

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