Article
B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
Biochemical and biophysical research communications - 4 Jan 2008
Matsumoto Koichiro, Fukuyama Satoru, Eguchi-Tsuda Miyuki, Nakano Takako, Matsumoto Takafumi, Matsumura Mikiko, Moriwaki Atsushi, Kan-o Keiko, Wada Yoshihiro, Yagita Hideo, Shin Tahiro, Pardoll Drew M, Patcharee Rirprajak, Azuma Miyuki, Nakanishi Yoichi, Inoue Hiromasa
Abstract excerpt
B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-gamma-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on...
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