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Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice

1 Nov 2007

Abstract excerpt

Abnormal angiogenesis plays a key role in diseases of aging such as heart disease, certain cancers, and eye diseases including age-related macular degeneration. Macrophages have been shown previously to be both anti- and proangiogenic, and their role in regulating angiogenesis at sites of tissue injury is critical and complex. In this study, we analyzed cytokine gene expression patterns of mouse macrophages by...

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PMID: 17975672
DOI: 10.1172/jci32430

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