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Article

Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis.

Diabetic medicine : a journal of the British Diabetic Association - 1 Dec 2007

Spoletini M, Petrone A, Zampetti S, Capizzi M, Zavarella S, Osborn J, Foffi C, Tuccinardi D, Pozzilli P, Buzzetti R

Abstract excerpt

AIMS: The role of human leukocyte antigen (HLA) genes in the susceptibility to Type 1 diabetes (T1DM) is well known. However, we do not know whether the degree of pancreatic B-cell destruction depends on different HLA genetic risk. The aim of this study was to analyse the influence of DRB1* and DQB1* genes on the rate of pancreatic B-cell loss in a prospective series of 120 consecutive newly diagnosed T1DM...

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Identifiers

PMID: 17971177
DOI: 10.1111/j.1464-5491.2007.02292.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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