Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of genetic risk load defined by HLA-DQB1 polymorphism on clinical characteristics of IDDM in children.

European journal of clinical investigation - 1 Feb 1995

Veijola R, Knip M, Reijonen H, Vähäsalo P, Puukka R, Iionen J

Abstract excerpt

Clinical and autoimmune characteristics of 150 diabetic children of mean age 7.8 years (SD 4.1 years) were recorded at clinical manifestation and during the first 2 years of IDDM in order to investigate whether subjects with high risk HLA-DQB1 genotypes differ from those without these risk markers. When comparing subjects with the DQB1*0302/0201, DQB1*0302/x, DQB1*0201/x, or other DQB1 genotypes (x = no...

Topics

Adolescent
Alleles
C-Peptide
Child
Child, Preschool
Diabetes Mellitus, Type 1
Female
Genotype
HLA-DQ Antigens
HLA-DQ beta-Chains
Histocompatibility Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Male

Polymorphism, Genetic

Risk Factors

Source

Identifiers

PMID: 7737259
DOI: 10.1111/j.1365-2362.1995.tb01534.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7737259-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of genetic risk load defined by HLA-DQB1 polymorphism on clinical characteristics of IDDM in children.PMID 7737259Read ↗

Autoimmune and clinical characteristics of type I diabetes in children with different genetic risk loads defined by HLA-DQB1 alleles. Childhood Diabetes in Finland Study Group.Semantic proximity Read ↗

HLA-DQB1-defined genetic susceptibility, beta cell autoimmunity, and metabolic characteristics in familial and nonfamilial insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype.Semantic proximity Read ↗

Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus. The Swedish Childhood Diabetes Study Group and The Diabetes Incidence in Sweden Study (DISS) Group.Semantic proximity Read ↗

Relationship between HLA-DQ and -DR genotypes and clinical characteristics in a French population of Type 1 diabetic patients.Semantic proximity Read ↗

Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions.Semantic proximity Read ↗

Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.Semantic proximity Read ↗

Role of HLA-DPrs3077 and HLA-DQrs3920 Polymorphisms as Risk Factors for Type 1 Diabetes Mellitus.Semantic proximity Read ↗

[Biological differences on onset among type 1A diabetics in relation to HLA-DQ genetic markers].Semantic proximity Read ↗

Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.Semantic proximity Read ↗

Human leukocyte antigen identity and DQ risk alleles in autoantibody-positive siblings of children with IDDM are associated with reduced early insulin response. Childhood Diabetes in Finland (DiMe) Study Group.Semantic proximity Read ↗

HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.