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Article

Mutations as trapdoors to two competing native conformations of the Rop-dimer.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2007

Schug Alexander, Whitford Paul C, Levy Yaakov, Onuchic José N

Abstract excerpt

Conformational transitions play a central role in regulating protein function. Structure-based models with multiple basins have been used to understand the mechanisms governing these transitions. A model able to accommodate multiple folding basins is proposed to explore the mutational effects in the folding of the Rop-dimer (Rop). In experiments, Rop mutants show unusually strong increases in folding rates with...

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Identifiers

PMID: 17968016
DOI: 10.1073/pnas.0706077104
PMCID: PMC2077020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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