Article
Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors.
Advances in experimental medicine and biology - 1 Jan 2007
Knirel Yuriy A, Dentovskaya Svetlana V, Bystrova Olga V, Kocharova Nina A, Senchenkova Sof'ya N, Shaikhutdinova Rima Z, Titareva Galina M, Bakhteeva Irina V, Lindner Buko, Pier Gerald B, Anisimov Andrey P
Abstract excerpt
Disruption of lipopolysaccharide (LPS) biosynthesis genes in an epidemiologically significant Yersinia pestis strain showed that the ability to synthesize the full inner core of the LPS is crucial for resistances to the bactericidal action of antimicrobial peptides and to complement-mediated serum killing. Resistance to polymyxin B also requires a high content of the cationic sugar, 4-amino-4-deoxy-L-arabinose,...
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