Article
Immunodeficiency due to mutations in ORAI1 and STIM1.
Clinical immunology (Orlando, Fla.) - 1 May 2010
Feske Stefan, Picard Capucine, Fischer Alain
Abstract excerpt
Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is localized in the ER where it senses the concentration of stored Ca(2+). Following antigen binding to immunoreceptors...
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