Article
The Odyssey of MeCP2 and parental imprinting.
Epigenetics - 1 Jan 2000
LaSalle Janine M
Abstract excerpt
DNA methylation in mammals has long been implicated in the epigenetic mechanism of parental imprinting, in which selective expression of one allele of specific genes is based on parental origin. Methyl CpG binding protein 2 (MeCP2) selectively binds to methylated DNA and mutations in the MECP2 cause the autism-spectrum neurodevelopmental disorder Rett syndrome. This review outlines the emerging story of how MeCP2...
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