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Article

Stability and kinetic properties of C5-domain from myosin binding protein C and its mutants.

Biophysical journal - 15 Feb 2008

Guardiani Carlo, Cecconi Fabio, Livi Roberto

Abstract excerpt

The impact of three mutations of domain C5 from myosin binding protein C, correlated to Familial Hypertrophic Cardiomyopathy, has been assessed through molecular dynamics simulations based on a native centric protein modeling. The severity of the phenotype correlates with the shift in unfolding temperature determined by the mutations. A contact probability analysis reveals a folding process of the C5 domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17965135
DOI: 10.1529/biophysj.107.106625
PMCID: PMC2212681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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