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Article

Computational analysis of folding and mutation properties of C5 domain of myosin binding protein C.

Proteins - 1 Mar 2008

Guardiani Carlo, Cecconi Fabio, Livi Roberto

Abstract excerpt

Thermal folding molecular dynamics simulations of the domain C5 of Myosin binding protein C were performed using a native-centric model to study the role of three mutations related to Familial Hypertrophic Cardiomyopathy. Mutation of Asn755 causes the largest shift of the folding temperature, and the residue is located in the CFGA' beta-sheet featuring the highest phi-values. The mutation thus appears to reduce...

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Identifiers

PMID: 17876814
DOI: 10.1002/prot.21621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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