Article
A nonfunctioning single nucleotide polymorphism in olfactory receptor gene family is associated with the forced expiratory volume in the first second/the forced vital capacity values of pulmonary function test in a Japanese population.
Biochemical and biophysical research communications - 21 Dec 2007
Takabatake Noriaki, Toriyama Sayumi, Takeishi Yasuchika, Shibata Yoko, Konta Tsuneo, Inoue Sumito, Abe Shuichi, Igarashi Akira, Tokairin Yoshikane, Ishii Miho, Koyano Satoru, Emi Mitsuru, Kato Takeo, Kawata Sumio, Kubota Isao
Abstract excerpt
The forced expiratory volume in the first second (FEV1.0)/the forced vital capacity (FVC) is an important index of a single forced expiration. Ectopic expression of the human olfactory receptor (OR) gene family in the lungs has suggested its potential involvement of respiratory physiology. We hypothesized that the individual variability of FEV1.0/FVC value may be attributed to the genetic variance of the OR gene...
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