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Article

Structure-activity correlations in pentachlorobenzene oxidation by engineered cytochrome P450cam.

Protein engineering, design & selection : PEDS - 1 Oct 2007

Xu Feng, Bell Stephen G, Rao Zihe, Wong Luet-Lok

Abstract excerpt

We had reported engineering of the heme monooxygenase cytochrome P450cam from Pseudomonas putida with the F87W/Y96F/L244A/V247L mutations for the oxidation of pentachlorobenzene (PeCB), a recalcitrant environmental contaminant, to pentachlorophenol. In order to provide further insights into P450 structure, function and substrate recognition, we have determined the crystal structure of this 4-mutant without a...

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Identifiers

PMID: 17962225
DOI: 10.1093/protein/gzm028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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