Article
Effects of follicle-stimulating hormone and human chorionic gonadotropin on gonadal steroidogenesis in two siblings with a follicle-stimulating hormone beta subunit mutation.
Fertility and sterility - 1 Oct 2008
Lofrano-Porto Adriana, Casulari Luiz Augusto, Nascimento Paula P, Giacomini Leonardo, Naves Luciana A, da Motta Lucilia Domingues Casulari, Layman Lawrence C
Abstract excerpt
OBJECTIVE: To quantify gonadal steroid responses to different gonadotropin regimens. DESIGN: Transversal clinical study. SETTING: Academic medical center. PATIENT(S): A 41-year-old woman and her 37-year-old brother with isolated FSH deficiency due to a homozygous Tyr76X FSH beta subunit gene (FSHB) mutation. INTERVENTION(S): Initially, serial LH samples were drawn overnight. After 2-day dexamethasone suppression,...
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