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Article

Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes.

International journal of colorectal disease - 1 Feb 2008

Grünhage Frank, Jungck Matthias, Lamberti Christoph, Berg Christine, Becker Ursula, Schulte-Witte Hildegard, Plassmann Dominik, Rahner Nils, Aretz Stefan, Friedrichs Nicolaus, Buettner Reinhard, Sauerbruch Tilman, Lammert Frank

Abstract excerpt

INTRODUCTION: About 20% of colorectal cancer (CRC) patients show some kind of familiarity, which might be caused by yet unknown combinations of low penetrance susceptibility genes. We aimed to identify genetic factors for familial CRC (fCRC) in a unique study design that includes phenotypic extremes as represented by fCRC cases and 'hyper-normal' controls without CRC history and no adenomatous polyps on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17960397
DOI: 10.1007/s00384-007-0388-6

Genes

CCND1
CDH1
VDR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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