Article
Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibility: a case-control study.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2014
Govatati Suresh, Singamsetty Gopi Krishna, Nallabelli Nayudu, Malempati Sravanthi, Rao Pasupuleti Sreenivasa, Madamchetty Venkata Kranthi Kumar, Govatati Sowdamani, Kanapuram Rudramadevi, Narayana Nagesh, Bhanoori Manjula, Kassetty Kondaiah, Nallanchakravarthula Varadacharyulu
Abstract excerpt
Cyclin D1 (CCND1) and E-cadherin (CDH1) are two important genes of the β-catenin/LEF pathway that is involved in tumorigenesis of various cancers including colorectal cancer (CRC). However, studies of the association between genetic variants of these two genes and CRC have shown conflicting results. We conducted a genetic association study in South Indian population (cases, 103; controls, 107) to assess the...
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