Article
Subjects with chronic lymphocytic leukaemia-like B-cell clones with stereotyped B-cell receptors frequently show MDS-associated phenotypes on myeloid cells.
British journal of haematology - 1 Jan 2015
Rodríguez-Caballero Arancha, Henriques Ana, Criado Ignacio, Langerak Anton W, Matarraz Sergio, López Antonio, Balanzategui Ana, González Marcos, Nieto Wendy G, Cortesão Emília, Paiva Artur, Almeida Julia, Orfao Alberto
Abstract excerpt
An increasing body of evidence suggests the potential occurrence of antigen encounter by the cell of origin in chronic lymphocytic leukaemia (CLL) and CLL-like monoclonal B-cell lymphocytosis (MBL). However, the scenario in which this event might occur remains unknown. In order to gain insight into this scenario we investigated the molecular, cytogenetic and haematological features of 223 CLL-like (n = 84) and...
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