Article
CYP2C9 genotypes and the quality of anticoagulation control with warfarin therapy among Brazilian patients.
European journal of clinical pharmacology - 1 Jan 2008
Lima M V, Ribeiro G S, Mesquita E T, Victer P R, Vianna-Jorge R
Abstract excerpt
OBJECTIVE: To evaluate the impact of the two most common CYP2C9 variant alleles (*2 and *3) on the maintenance dose of warfarin and on the quality of anticoagulation control in Brazilians. METHODS: Patients (n = 103) initiated warfarin therapy with 5 mg/day (or 2.5 mg/day when over 80 years old). The international normalized ratio (INR) was targeted between 2 and 3, monitored every week until four consecutive...
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