Article
Frequency of CYP2C9 polymorphisms affecting warfarin metabolism in a large anticoagulant clinic cohort.
Clinical biochemistry - 1 Jun 2006
Moridani Majid, Fu Lei, Selby Rita, Yun Francisco, Sukovic Tatjana, Wong Betty, Cole David E C
Abstract excerpt
OBJECTIVES: To assess allele frequency and genotype distribution of CYP2C9 polymorphisms in patients (n = 189) attending an anticoagulant clinic in comparison to control patients (n = 177) and also to assess if the patients with variant genotypes require lower doses of warfarin. METHODS: Genotyping of the common CYP2C9 variants *2 and *3 was carried out by multiplexed PCR-RFLP while the *5 and *6 allele variants...
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