Article
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
Cancer science - 1 Jan 2008
Nakamura Yu, Matsubara Daisuke, Goto Akiteru, Ota Satoshi, Sachiko Oguni, Ishikawa Shumpei, Aburatani Hiroyuki, Miyazawa Keiji, Fukayama Masashi, Niki Toshiro
Abstract excerpt
In this study we explored the mechanisms of constitutive activation of c-Met in lung adenocarcinoma cell lines. First, we examined levels of c-Met and phospho-c-Met (Y1234/Y1235) in a panel of lung adenocarcinoma cell lines by Western blot analysis. c-Met expression was found in 12 of 14 cell lines and an overall correlation between the expressions of c-Met and phospho-c-Met was noted. c-Met was constitutively...
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