Article
MET phosphorylation predicts poor outcome in small cell lung carcinoma and its inhibition blocks HGF-induced effects in MET mutant cell lines.
British journal of cancer - 6 Sept 2011
Arriola E, Cañadas I, Arumí-Uría M, Dómine M, Lopez-Vilariño J A, Arpí O, Salido M, Menéndez S, Grande E, Hirsch F R, Serrano S, Bellosillo B, Rojo F, Rovira A, Albanell J
Abstract excerpt
BACKGROUND: Small cell lung carcinoma (SCLC) has poor prognosis and remains orphan from targeted therapy. MET is activated in several tumour types and may be a promising therapeutic target. METHODS: To evaluate the role of MET in SCLC, MET gene status and protein expression were evaluated in a panel of SCLC cell lines. The MET inhibitor PHA-665752 was used to study effects of pathway inhibition in basal and...
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