Article
Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture.
International journal of radiation biology - 1 Jan 2000
Lacina Lukas, Dvoránkova Barbora, Smetana Karel, Chovanec Martin, Plzák Jan, Tachezy Ruth, Kideryová Linda, Kucerová L, Cada Zdenek, Boucek Jan, Kodet R, André S, Gabius Hans-Joachim
Abstract excerpt
PURPOSE: The microenvironment established by stromal cells may or may not influence phenotypic aspects of epithelial cells and may be relevant for tumor and stem cell biology. We address this issue for keratinocytes using tumor-derived stromal cells in a co-culture system. MATERIALS AND METHODS: We isolated stromal cells from human squamous cell carcinoma tissue and studied their effect on phenotypic...
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