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Article

Algorithms for selecting breakpoint locations to optimize diversity in protein engineering by site-directed protein recombination.

Computational systems bioinformatics. Computational Systems Bioinformatics Conference - 1 Jan 2007

Zheng Wei, Ye Xiaoduan, Friedman Alan M, Bailey-Kellogg Chris

Abstract excerpt

Protein engineering by site-directed recombination seeks to develop proteins with new or improved function, by accumulating multiple mutations from a set of homologous parent proteins. A library of hybrid proteins is created by recombining the parent proteins at specified breakpoint locations; subsequent screening/selection identifies hybrids with desirable functional characteristics. In order to improve the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17951810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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