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Article

Structural effects of extracellular loop mutations in CFTR helical hairpins.

Biochimica et biophysica acta. Biomembranes - 1 May 2018

Chang Yuan-Heng, Stone Tracy A, Chin Stephanie, Glibowicka Mira, Bear Christine E, Deber Charles M

Abstract excerpt

Missense mutations constitute 40% of 2000 cystic fibrosis-phenotypic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) database, yet the precise mechanism as to how a point mutation can render the entire 1480-residue CFTR protein dysfunctional is not well-understood. Here we investigate the structural effects of two CF-phenotypic mutations - glutamic acid to glycine at position 217...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29307731
DOI: 10.1016/j.bbamem.2018.01.003

Genes

CFTR
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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