Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2008

Hill Shirley Y, Hoffman Eric K, Zezza Nicholas, Thalamuthu Anbupalam, Weeks Daniel E, Matthews Abigail G, Mukhopadhyay Indranil

Abstract excerpt

Animal and human studies of addiction indicate that the D2 dopamine receptor (DRD2) plays a critical role in the mechanism of drug reward. D2 receptor density in the brains of alcoholics has been shown to be reduced relative to controls. Previous studies of DRD2 in association with alcohol dependence using variation in the TaqI A locus were highly controversial. Recently, a synonymous mutation, C957T, in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Linkage Disequilibrium

Share to Nuclear Family

Share to Pedigree

Share to Point Mutation

Share to Receptors, Dopamine D2

Source

Open in PubMed Open full text

Identifiers

PMID: 17948902
DOI: 10.1002/ajmg.b.30630
PMCID: PMC3280909

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families.PMID 17948902Read ↗

Association and family studies of DRD2 gene polymorphisms in alcohol dependence syndrome.Semantic proximity Read ↗

Alcoholism and alleles of the human D2 dopamine receptor locus. Studies of association and linkage.Semantic proximity Read ↗

Association of the dopamine D2 receptor gene with alcohol dependence: haplotypes and subgroups of alcoholics as key factors for understanding receptor function.Semantic proximity Read ↗

Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.Semantic proximity Read ↗

A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism.Semantic proximity Read ↗

A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism.Semantic proximity Read ↗

Population-based case-control study of DRD2 gene polymorphisms and alcoholism.Semantic proximity Read ↗

The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses.Semantic proximity Read ↗

Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults.Semantic proximity Read ↗

Family-based study of DRD2 alleles in alcohol and drug dependence.Semantic proximity Read ↗

The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes.Semantic proximity Read ↗

The D2 dopamine receptor gene and alcoholism: a genetic effect in the liability for alcoholism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.