Article
Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults.
Journal of studies on alcohol and drugs - 1 May 2007
Haberstick Brett C, Timberlake David, Smolen Andrew, Sakai Joseph T, Hopfer Christian J, Corley Robin P, Young Susan E, Stallings Michael C, Huizinga David, Menard Scott, Hartman Christy, Grotpeter Jennifer, Hewitt John K
Abstract excerpt
OBJECTIVE: Dopaminergic dysfunction has been hypothesized to play an important role in the etiology of alcohol-use disorders. A restriction fragment length polymorphism (RFLP) in the 3' untranslated region (3'UTR) of the DRD2 gene affects gene expression and has been implicated as a risk factor for alcohol dependence. This polymorphism (TaqIA) has been reported as positively associated with alcohol-use disorders...
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