Article
A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism.
The British journal of psychiatry : the journal of mental science - 1 Aug 1996
Cook C C, Palsson G, Turner A, Holmes D, Brett P, Curtis D, Petursson H, Gurling H M
Abstract excerpt
BACKGROUND: Reports of an association between restriction fragment length polymorphisms (RFLPs) at the dopamine D2 receptor (DRD2) locus and alcoholism have suggested involvement of that locus in the aetiology of alcoholism. METHOD: Sib pair linkage analyses were conducted in families multiply affected by alcoholism, using both the Taql 'A' RFLP and a microsatellite repeat polymorphism at the DRD2 locus. RESULTS:...
Topics
- Alcoholism
- Alleles
- Female
- Humans
- Male
- Polymorphism, Genetic
- Receptors, Dopamine D2