Article
Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism.
Breast cancer research : BCR - 1 Jan 2007
Gochhait Sailesh, Bukhari Syed Irfan Ahmad, Bairwa Narendra, Vadhera Shivani, Darvishi Katayoon, Raish Mohammad, Gupta Pawan, Husain Syed Akhtar, Bamezai Rameshwar N K
Abstract excerpt
INTRODUCTION: The absence of mutation or promoter hypermethylation in the BRCA2 gene in the majority of breast cancer cases has indicated alternative ways of its involvement, deregulated expression being one possibility. We show how a polymorphism in the 5' untranslated region (UTR) of BRCA2 can serve as one such factor. Based on the hypothesis that variants of genes involved in the same pathway can influence the...
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