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IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population.

Cancer genetics and cytogenetics - 15 Oct 2008

Vishnoi Monika, Pandey Sachchida Nand, Choudhuri Gourdas, Mittal Balraj

Abstract excerpt

Long-standing gallstones are generally present in 65-80% patients of gallbladder cancer (GBC). It has also been suggested that inflammation caused by gallstones may be involved in the development of GBC. Interleukin-1 receptor antagonist (IL-1RN) and interleukin-1 beta (IL-1B) are proinflammatory cytokine genes at the interleukin-1 locus, and polymorphisms of these genes have been associated with various...

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PMID: 18940468
DOI: 10.1016/j.cancergencyto.2008.05.004

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