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Article

Simulating evolution of protein complexes through gene duplication and co-option.

Journal of theoretical biology - 21 Jun 2016

Haarsma Loren, Nelesen Serita, VanAndel Ethan, Lamine James, VandeHaar Peter

Abstract excerpt

We present a model of the evolution of protein complexes with novel functions through gene duplication, mutation, and co-option. Under a wide variety of input parameters, digital organisms evolve complexes of 2-5 bound proteins which have novel functions but whose component proteins are not independently functional. Evolution of complexes with novel functions happens more quickly as gene duplication rates...

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Identifiers

PMID: 27038665
DOI: 10.1016/j.jtbi.2016.03.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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