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Article

The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family

8 Sept 2009

Abstract excerpt

BACKGROUND: The glutamate receptors (GluRs) play a vital role in the mediation of excitatory synaptic transmission in the central nervous system. To clarify the evolutionary dynamics and mechanisms of the GluR genes in the lineage leading to humans, we determined the complete sequences of the coding regions and splice sites of 26 chimpanzee GluR genes. RESULTS: We found that all of the reading frames and splice...

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PMID: 19737383
DOI: 10.1186/1471-2148-9-224

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