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Article

Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke.

PloS one - 17 Oct 2007

Abboud Shérine, Karhunen Pekka J, Lütjohann Dieter, Goebeler Sirkka, Luoto Teemu, Friedrichs Silvia, Lehtimaki Terho, Pandolfo Massimo, Laaksonen Reijo

Abstract excerpt

BACKGROUND/PURPOSE: Genetic variation in proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been recently identified as an important determinant of plasma LDL-cholesterol and severity of coronary heart disease. We studied whether the PCSK9 gene is linked to the risk of ischemic stroke (IS) and with the development of intracranial atherosclerosis. METHODS/RESULTS: The pivotal E670G polymorphism,...

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Source

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Identifiers

PMID: 17940607
DOI: 10.1371/journal.pone.0001043
PMCID: PMC2002510

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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