Article
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.
Nature medicine - 1 Nov 2007
Ray Sandip, Britschgi Markus, Herbert Charles, Takeda-Uchimura Yoshiko, Boxer Adam, Blennow Kaj, Friedman Leah F, Galasko Douglas R, Jutel Marek, Karydas Anna, Kaye Jeffrey A, Leszek Jerzy, Miller Bruce L, Minthon Lennart, Quinn Joseph F, Rabinovici Gil D, Robinson William H, Sabbagh Marwan N, So Yuen T, Sparks D Larry, Tabaton Massimo, Tinklenberg Jared, Yesavage Jerome A, Tibshirani Robert, Wyss-Coray Tony
Abstract excerpt
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic...
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