Article
Association of Met439Thr substitution in heat shock protein 70 gene with postoperative atrial fibrillation and serum HSP70 protein levels.
Cardiology - 1 Jan 2008
Afzal Ali R, Mandal Kaushik, Nyamweya Samuel, Foteinos Georgios, Poloniecki Jan, Camm A John, Jahangiri Marjan, Xu Qingbo
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia encountered following cardiac surgery. Previously, we have shown that higher expression of heat shock protein (HSP) 70 was associated with decreased incidence of postoperative AF (PoAF), suggestive of an antiarrhythmic role. OBJECTIVE: We have hypothesised that Met493Thr substitution of one of the important hsp70 genes may cause loss of these protective...
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