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Article

Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).

Neuroscience letters - 5 Nov 2007

Yiangou Yiangos, Facer Paul, Chessell Iain P, Bountra Chas, Chan Chris, Fertleman Caroline, Smith Virpi, Anand Praveen

Abstract excerpt

Faecal urgency and incontinence with rectal hypersensitivity is a chronic, unexplained condition that is difficult to treat. The aim of this study was to determine if there was an altered level of the voltage gated tetrodotoxin-sensitive (TTX-s) sodium channel Na(v)1.7 in rectal sensory fibres, since this channel has been implicated in clinical nociceptive disorders. Full thickness rectal biopsies from patients...

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Source

Identifiers

PMID: 17928139
DOI: 10.1016/j.neulet.2007.09.027

Genes

TRPV1
NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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