Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).

doi:10.1016/j.neulet.2007.09.027

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Article

Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).

Neuroscience letters - 5 Nov 2007

Yiangou Yiangos, Facer Paul, Chessell Iain P, Bountra Chas, Chan Chris, Fertleman Caroline, Smith Virpi, Anand Praveen

Abstract excerpt

Faecal urgency and incontinence with rectal hypersensitivity is a chronic, unexplained condition that is difficult to treat. The aim of this study was to determine if there was an altered level of the voltage gated tetrodotoxin-sensitive (TTX-s) sodium channel Na(v)1.7 in rectal sensory fibres, since this channel has been implicated in clinical nociceptive disorders. Full thickness rectal biopsies from patients...

Topics

Adult
Aged
Aged, 80 and over
Biopsy
Fecal Incontinence
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NAV1.7 Voltage-Gated Sodium Channel

Nerve Fibers

Neurons, Afferent

Rectum

Sodium Channels

Somatoform Disorders

Source

Open in PubMed

Identifiers

PMID: 17928139
DOI: 10.1016/j.neulet.2007.09.027

Genes

TRPV1
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17928139-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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